• - Professional employement
• - Education
• - Publications
• - Fundings

• Dr. Izard's professional path (resume in pdf format)

• - By funding a research project
• - By funding a trainee
• - By funding an equipment
• 
  
• - By joining the laboratory

Permanent-resident status in the U.S.A. - French citizen

Research Goal: Understanding the relationship between the oral microbiome and the host, in the search for new drug targets to fight oral diseases and promote healing

• 2008-present: Board member of the International Association for the Biological and Medical Research (IABMR); Co-chair of the Fund-Raising Committee.
• 2007-present: Assistant Member of the Staff, The Forsyth Institute, Boston, MA.
• 2007-present: Elected Member of the Forsyth’s Partnership Working Group, Boston, MA.
• 2005-present: Harvard Instructor in Oral Medicine, Infection and Immunity, Harvard School of

            Dental Medicine, Boston, MA.

• 2004-present: Editorial Board member of BMC Biochemistry.
• 2002-present: Adjunct Assistant Professor, School of Public Health, Biomedical Sciences Graduate

Program, Immunology and Infectious Disease, SUNY Albany, Albany, NY.

• 2005-2007: Harvard Instructor in Oral and Developmental Biology, Harvard School of Dental

Medicine, Boston, MA.

• 2005-2007: Staff Associate, The Forsyth Institute, Boston, MA.
• 2004-2007: Visiting scientist, Wadsworth Center, Albany, NY.
• June 04-Feb 05: John W. Hein Research Fellow, The Forsyth Institute, Boston, MA.

Project: Cell biology of Treponema and its relation to pathogenicity.

• Dec. 98-May 04: Research Scientist I (Dec. 98-Apr. 00), Research Scientist II (Apr. 00-May 04) in the laboratory directed by Dr. Ronald Limberger. Wadsworth Center, New York State Department of Health, Albany, NY.

Project: Structure and function of cytoplasmic filaments in spirochetes.

• Apr. 96-Dec. 98: Research Affiliate in the laboratory directed by Dr. Ronald Limberger.

Wadsworth Center, New York State Department of Health, Albany, NY.

Project: Function of cytoplasmic filaments in spirochetes.

• Oct. 95-March 96: Post-doctoral position at the Macromolecular-System Engineering.

Laboratory directed by Dr. Claude Lazdunski, Marseille, France.

Short term fellowship from “Fondation pour la Recherche Médicale”.

Project: Modification of the specificity of the colicin A channel.

• 1996 Ph.D., Cellular Biology and Microbiology, University of Aix-Marseille II, France.

Advisor: Dr. Daniel Baty. Laboratory: Dr. Claude Lazdunski (CNRS).

Doctoral fellowship from the French government.

Project: Understanding the insertion mechanism of a soluble protein in the inner membrane of Gram-negative bacteria: the toxic effect of colicin A. 

• 1992 Master of Science, Major in Cellular Biology and Microbiology, University of Provence,

Marseille, France. Fellowship from Conseil Général des Bouches du Rhônes. Project: Tryptophan

mutagenesis of the C-terminal fragment of colicin A for fluorescence studies.

• 1990 Bachelor of Science, Major in Biochemistry, University of Sciences & Techniques of Languedoc, Montpellier, France.

• Jacques Izard*, Chyong-Ere Hsieh, Ronald J. Limberger, Carmen A. Mannella and Mike Marko.
  Native cellular architecture of  Treponema denticola revealed by cryo-electron tomography.
  Journal of Structural Biology (2008). Vol.163 (1) pp. 10-17.
  
  
• Julia Downes, Sonia Vartoukian, Floyd E. Dewhirst, Jacques Izard, Tsute Chen, Wenhan Yu and William G. Wade.
  Pyramidobacter pisciolens gen. nov., sp. nov., a member of the phylum ‘Synergistetes’ isolated from the human oral cavity.
  International Journal of Systematic and Evolutionary Microbiology (2008). Accepted for publication.
  
  
• Jacques Izard*.
  Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein family.
  Journal of Molecular Microbiology and Biotechnology (2006). Vol. 11 pp. 159-166.
  
  
• Federico Foschi, Jacques Izard, Hajime Sasaki, Victorio Sambri, Carlo Prati, Ralph Müller, and Philip Stashenko.
  Treponema denticola in disseminating endodontic infections. (Cover)
  Journal of Dental Research (2006). vol. 85 (8) pp.761-765.
  
  
• Jacques Izard, and Ronald J. Limberger.
  Structural and genomic features of treponemal architecture.
  Book Chapter in: Treponema molecular and cellular biology.
  J. Radolf and S.A. Lukehart (ed.) Horizon Bioscience (2006). ISBN 1-904455-10-7.
  [To get a complete description and to buy the book from Caister Academic Press, click here]
  
  
• Anne C. R. Tanner and Jacques Izard.
  Tannerella forsythia, a periodontal pathogen entering the genomic era.
  Periodontology 2000 (2006). vol. 42 pp. 88-113.
  
  
• Jacques Izard*, Chyongere-E. Hsieh, Carmen A. Mannella, Ronald J. Limberger, and Mike Marko.
  Periplasm organization in Treponema denticola as studied by cryo-electron tomography.
  Microscopy and Microanalysis (2005) vol. 11 (Suppl 2) pp340-341.[pdf file]
  
  
• Anne C. R. Tanner and Jacques Izard.
  Etiology of oral disease in view of microbial complexity.
  Oral Biosciences & Medicine (2005) vol.2 n. 2/3 pp. 209-213.
  
  
• Linda Slivienski-Gebhardt, Jacques Izard, William A. Samsonoff, and Ronald J. Limberger.
  Development of a novel chloramphenicol-resistance expression plasmid used for genetic complementation of a fliG-deletion mutant of Treponema denticola.
  Infection Immunity (2004), vol. 72(9) pp. 5493-5497.
  [Infection Immunity - web site]
  
  
• Jacques Izard*, Bruce F. McEwen, Rita M. Barnard, Thomas Portuese, and Ronald J. Limberger.
  Tomographic reconstruction of treponemal cytoplasmic filaments reveals novel bridging and anchoring components.
  Molecular Microbiology.(2004) vol. 51 (3) pp. 609-618.
  [Molecular Microbiology at Blackwell Publishing - web site]
  
  
• Jacques Izard*, and Ronald J. Limberger.
  Rapid Screening Method for Quantitation of Bacterial Lipids from Whole Cells.
  Doi: 10.1016/S0167-7012(03)00193-3..
  Journal of Microbiological Methods. (2003) vol. 55 n. 2, pp. 411-418.
  
  
• Jacques Izard* and Ronald J. Limberger.
  Pleiotropic Defects in a Treponema denticola Cytoplasmic Filament Mutant.
  Journal of Bacteriology (2001) vol. 183 n. 3 pp. 1078-1084.
  [Journal of Bacteriology - web site]
  
  
• Jacques Izard*, William. A. Samsonoff, Mary-Beth Coy and Ronald J. Limberger.
  Genetic and Structural Analysis of the Cytoplasmic Filaments of Wild-type and a Flagella Filament-deficient Isolate of Treponema phagedenis.
  Journal of Bacteriology (1999) vol. 181 n. 21 pp. 6739-6746
  [Journal of Bacteriology - web site]
  
  
• Ronald J. Limberger, Linda L. Slivienski, Jacques Izard and William A. Samsonoff.
  Insertional Inactivation of Treponema denticola tap1 Results in a Non-Motile Mutant with Elongated Flagellar Hooks.
  Journal of Bacteriology (1999) vol. 181 n. 12 pp. 3743-3750.
  [Journal of Bacteriology - web site]
  
  
• Denis Duché, Jacques Izard, Juan M. Gonzalez-Mañas, Michael W. Parker, Martine Chartier and Daniel Baty.
  Two Disulfide Bonds Introduced in the Colicin A Pore-forming Domain Block the in vivo but not the in vitro Toxin Activity.
  Journal of Biological Chemistry (1996) vol. 271 n°26, pp. 15401-15406.
  
  
• Rita Vos and Yves Engelborghs; Jacques Izard and Daniel Baty.
  Fluorescence Study of the Three Tryptophan Residues of the Pore-forming Domain of Colicin A Using Multifrequency Phase Fluorometry.
  Biochemistry (1995) vol. 34, pp. 1734-1743.
  
  
• Jacques Izard, Michael W. Parker, Martine Chartier, Denis Duché and Daniel Baty. A Single Amino Acid
  Substitution Can Restore the Solubility of Aggregated Colicin A Mutants in Escherichia coli.
  Protein Engineering (1994) vol. 7 n°12, pp. 1495-1500.
  [Protein Engineering has been relauched in 2004 as Protein Engineering, Design and Selection - web site]
  
  

• 2007-2009, Developmental grant of the National Institute of Dental and Craniofacial Research  (R21 DE017106).

Title: Treponema denticola cytoskeletal filaments and oral infection.

Effort: 35%. Amount: $275,000 (direct cost); $441,925 (total cost).

Role: Principal Investigator – Active funding

• 2006-2011, Cooperative agreement of the National Institute of Dental and Craniofacial Research (U01-DE-016937) – Floyd E. Dewhirst (Principal investigator)

Title: A foundation for the oral microbiome and metagenome

Effort: 40%. Amount: $2,256,783 (direct cost); $3,844,503 (total cost).

Role: Investigator – Active funding

• 2004-2006, John W. Hein Fellowship, funded by The Forsyth Institute.

Project: Cell biology and pathogenicity of Treponema denticola.

Effort 100%. Amount: $165,000 (total cost).

Role: Fellow

• 1998-2004, Research project grant of the National Institute of allergy and Infectious Diseases (R01AI034354) – Ronald J. Limberger (Principal investigator)

Title: A molecular analysis of treponemal motility genes.

Effort: 100%. Amount: $1,841,673 (direct cost)

Role: Investigator

• 1995, Short-term competitive fellowship funded by the “Fondation pour la Recherche Médicale”. Project: Modification of the specificity of the colicin A channel.

Effort: 100%. Duration: 6 months. Amount: about $12,000 (Salary, total cost).

Role: Fellow

• 1992-1995, Long-term competitive fellowship funded by the French government.

Project: Understanding the insertion mechanism of a soluble protein in the inner membrane of Gram-negative bacteria: the toxic effect of colicin A.

Effort: 100%. Amount: about $60,000 (Salary, total cost).

Role: Fellow