Triangle showing the relation of the laboratory themes and health and disease  

 

A laboratory at the Forsyth Institute,

Boston, MA

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Our mission is to understand the role of oral pathogens in oral disease severity and their influence in systemic disease progression

Our mission is to understand the role of oral pathogens in oral disease severity and their influence in systemic disease progression.
Our focus is on bacterial cell biology and the host response.

Research topics:
* Oral treponemes and Alzheimer's disease. The objective is to understand the influence of treponemes in the inflammatory process associated with Alzheimer's disease.
* Oral infection and risk factors for pancreatic cancer. We are investigating the importance of oral infection as a risk factor in patients with pancreatic cancer.
* Human Oral Microbiome Database (HOMD). We are providing a comprehensive data set of the genetic potential and phylogenetic diversity of oral bacteria to sustain the world research efforts on fastidious pathogens.
* Treponema denticola cytoplasmic filaments involvement in pathogenicity (CFPA). The objectives are to understand the implication of this intracellular structure in the pathogenicity of the bacteria at the infection site.
* Architecture and motility of Treponemes (FLA). To further our understanding of the cell architecture in dissemination we are examining the bacteria in its 3-dimensions, using tomography.

 
Contact Dr. Izard

 Last modified: June 9, 2009